Subramanian Vaidyanathan,1 Bakul M Soni,1 Paul Mansour,2 Tun Oo1 1Regional Spinal Injuries Centre, 2Department of Histopathology, Southport and Formby District General Hospital, Town Lane, Southport, UK Background: To identify areas for improvement, the National Health Service in England mandates the review of case reports of patients who have died
There are no effective therapeutics that antagonize or reverse the protein-misfolding events Wine Racks underpinning polyglutamine (PolyQ) disorders, including Spinocerebellar Ataxia Type-3 (SCA3).Here, we augment the proteostasis network of Drosophila SCA3 models with Hsp104, a powerful protein disaggregase from yeast, which is bafflingly absent f
Background There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs).The association between vitamin D deficiency during gestation, a critical period in Pickle neurodevelopment, and ASD is not well understood.Aims To determine the association between gestational vitamin D status and ASD.Method Based on a birth
The melanin-concentrating hormone (MCH) system plays a role in many physiological processes including reproduction and lactation.However, research regarding the function of MCH on different aspects of the reproductive function lags, due in part to a lack of validated genetic models with which to interrogate the system.This is particularly true in t